Almost 3.5 Seconds Time to First Byte?

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Thanks for the great suggestions - unfortunately "Optimize disk enhanced page" cannot be checked. Not sure what the problem is.

Regarding the other plugins, I've tried to disable the ones I have and they are few. Hasn't made much difference. I've gotten the TTFB down to only about 400-500ms but that still is a LOT of time in total as it's 717ms with DNS lookup, etc.

Thanks for helping me troubleshoot. Will look at New Relic but this is a mystery and it shouldn't be this hard!